I'm in Prague! I think this wins hand down for my worst flight experience ever. SFO to JFK leg I was stuck in the middle of a pack of about 8 under five-year-old kids - I think they were doing some sort of ill conceived multi-family trip to Germany. One little girl industriously colored for the entire six hours, but there were a few screamers and kickers in the bunch.
JFK to PRG was looking like a nice reasonable adult group. BUT, then I made the mistake of trying to be nice and switch seats with a man who was sitting 10 rows behind his wife. Which put me two seats away from the mother-of-all-screaming-kids. The four year-old little terror wouldn't stop kicking the seats, jumping up and down, and full-blown-tantrum screaming. I tried to slip in a couple of hours of sleep in between his tantrums, but it was mighty difficult.
All in all, I landed in Prague after 20 hours of traveling with about three hours of sleep. No rest for the weary though (or those that want to get on Central European Time ASAP), so I hit the streets of Prague for the next 9 hours. In the 85 degree humid heat.
Top-line summary of Prague: beautiful architecture, too many tourists. It's like being in Disneyland! Nothing looks real. (See below for evidence)

I hit up all the major Prague highlights my first day: Prague Castle, Charles Bridge, Old Town, New Town, Mucha Museum, Museum of Communism. Maybe it was my jet lag, maybe it was the tourists and the heat, but I didn't actually enjoy it very much. I felt like I was just going through the motions of being a tourist. Well, that's not exactly true. I really liked the two museums, probably because I escaped the hordes of tourists for a little while.